Search Result
Results for "
degradation product
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
13
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-113412A
-
|
Endogenous Metabolite
|
Inflammation/Immunology
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3-Methylhistamine dihydrochloride is a degradation product of histamine. 3-Methylhistamine dihydrochloride, a methylated product of histamine, is associated with immune response and shows upregulation in the vaccinated mice .
|
-
-
- HY-121899
-
Ibuprofen EP impurity J
|
Drug Metabolite
|
Others
|
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively .
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-
-
- HY-122542B
-
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PAI-1
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Cardiovascular Disease
|
PPACK TFA is a plasminogen activator (rt-PA) inhibitor. PPACK TFA can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK TFA also inhibits the binding of rt-PA to plasma protease inhibitors .
|
-
-
- HY-129072
-
-
-
- HY-133246
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Daclatasvir Impurity A
|
HCV
|
Infection
|
Monodes(N-carboxymethyl)valine Daclatasvir (Daclatasvir Impurity A) is the main degradation product of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
|
-
-
- HY-136185
-
|
Drug Metabolite
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Others
|
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin (HY-B0589) . Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
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-
-
- HY-113382
-
-
-
- HY-135586
-
-
-
- HY-121652
-
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Others
|
Others
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Mefox is a degradation product of folic acid (HY-16637) .
|
-
-
- HY-101417
-
Diethyl phosphoric acid
|
Endogenous Metabolite
|
Others
|
Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.
|
-
-
- HY-136381
-
N-Nitroso-N-(phosphonoMethyl)glycine sodium; Glyphosate-N-nitroso sodium
|
Drug Metabolite
|
Others
|
N-Nitrosoglyphosate sodium is the nitrosamine degradation product and synthetic impurity of glyphosate herbicide .
|
-
-
- HY-B1514
-
-
-
- HY-111742
-
|
Drug Metabolite
|
Others
|
Bifenazate-diazene is a major degradation product of Bifenazate. Bifenazate is a selective carbazate acaricide and an insecticide .
|
-
-
- HY-133248
-
|
Drug Metabolite
|
Others
|
Daclatasvir Impurity C is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
|
-
-
- HY-133247
-
|
Drug Metabolite
|
Others
|
Daclatasvir Impurity B is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
|
-
-
- HY-W012575
-
|
Endogenous Metabolite
|
Others
|
2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture.
|
-
-
- HY-135372
-
|
Drug Metabolite
|
Infection
|
Descarbamoyl cefuroxime is a degradation product of Cefuroxime. Descarbamoyl cefuroxime is also an intermediate for the synthesis of Cephalosporin antibiotics .
|
-
-
- HY-122207
-
|
Others
|
Infection
|
Erythromycin A enol ether is an acidic degradation product of Erythromycin A (macrolide antibiotic) and has no antibacterial effect .
|
-
-
- HY-125947
-
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Drug Metabolite
|
Others
|
4-Epioxytetracycline, the degradation product of Oxytetracycline (OTC), can be found in swine manure compost and wastewater .
|
-
-
- HY-W010593
-
|
Others
|
Cancer
|
Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .
|
-
-
- HY-126606
-
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Others
|
Infection
|
Isochlortetracycline is an inactive alkaline degradation product of the Chlortetracycline (HY-B1327A) (broad-spectrum antibiotic) .
|
-
-
- HY-135577
-
|
Drug Metabolite
|
Infection
|
β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic .
|
-
-
- HY-137196
-
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Bacterial
|
Infection
|
Anhydrochlortetracycline hydrochloride is a degradation product of chlortetracycline (HY-B1327A). Anhydrochlortetracycline hydrochloride inhibits the growth of actinomycetes .
|
-
-
- HY-113137
-
-
-
- HY-112057
-
LY267108
|
Drug Metabolite
|
Others
|
Pseudoerythromycin A enol ether (LY267108) is a degradation product of Erythromycin. Pseudoerythromycin A enol ether has no significant antimicrobial activity .
|
-
-
- HY-112811
-
|
PROTACs
CDK
|
Cancer
|
PROTAC CDK9 degrader-2 (compound 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC .
|
-
-
- HY-100096
-
Emtricitabine sulfoxide; Emtricitabine Degradant-III
|
|
|
Emtricitabine S-oxide (Emtricitabine sulfoxide) is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.
|
-
-
- HY-N7007
-
|
Others
|
Metabolic Disease
|
Sclareol glycol is the precursor of ambroxide. Hyphozyma roseonigra ATCC 20624 was the only reported strain capable of degrading sclareol to the main product of sclareol glycol .
|
-
-
- HY-147001
-
-
-
- HY-125374A
-
XRP9881 dihydrate
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Others
|
Cancer
|
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors .
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-
-
- HY-W018171
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TCPy
|
Others
|
Others
|
3,5,6-Trichloro-2-pyridinol (TCPy) is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and Chlorpyrifos-methyl .
|
-
-
- HY-13938
-
Iretol
1 Publications Verification
|
Endogenous Metabolite
|
Metabolic Disease
|
Iretol (2,4,6-trihydroxyanisole) is a a degradation product of a glucoside obtained from Iris Jorentina. Iretol is an intermediate in the synthesis of natural isoflavones, such as Tectorigenin, Irigenin and Caviunin .
|
-
-
- HY-B0300S
-
-
-
- HY-101417S1
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Diethyl phosphoric acid-d10
|
Endogenous Metabolite
|
Others
|
Diethyl phosphate-d10-1 is the deuterium labeled Diethyl phosphate[1]. Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.
|
-
-
- HY-W017389
-
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
|
-
-
- HY-N7449
-
-
-
- HY-132995
-
|
Drug Metabolite
|
Others
|
DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity .
|
-
-
- HY-113432
-
2PY
|
Endogenous Metabolite
PARP
|
Metabolic Disease
|
Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
|
-
-
- HY-W010593S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Ethylenethiourea-d4 is the deuterium labeled Ethylenethiourea[1]. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active[2][3].
|
-
-
- HY-P4386
-
|
GLP Receptor
|
Metabolic Disease
|
(Asp28)-Exenatide is a degradation product of exenatide (HY-13443). (Asp28)-Exenatide can be used as a GLP-1R agonist .
|
-
-
- HY-N7387
-
|
Endogenous Metabolite
|
Metabolic Disease
|
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .
|
-
-
- HY-115349
-
|
Bacterial
|
Infection
Neurological Disease
Cancer
|
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities .
|
-
-
- HY-P3675
-
|
GnRH Receptor
|
Endocrinology
|
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes .
|
-
-
- HY-122542
-
|
PAI-1
|
Cardiovascular Disease
|
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .
|
-
-
- HY-101981R
-
5'-Uridylic acid (Standard)
|
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk .
|
-
-
- HY-101981
-
5'-Uridylic acid
|
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate (5'-Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk .
|
-
-
- HY-125665
-
|
Apoptosis
|
Cardiovascular Disease
Cancer
|
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research .
|
-
-
- HY-P3674
-
|
GnRH Receptor
|
Endocrinology
|
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .
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-
-
- HY-W355700
-
|
Drug Metabolite
|
Infection
|
1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine is the main degradation product of deltamethrin metabolized by the prokaryotic protein (CYP6A14 and CYP6N6) complexes in vitro .
|
-
-
- HY-131122S
-
4-n-Nonylphenol-2,3,5,6-d4,OD
|
Estrogen Receptor/ERR
|
Others
|
4-Nonylphenol-d5 is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].
|
-
- HY-133597
-
|
Others
|
Others
|
4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase .
|
-
- HY-N7454
-
|
Antibiotic
Bacterial
|
Infection
|
Anhydroerythromycin A is a degradation product of the macrolide antibiotic erythromycin. Anhydroerythromycin A is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 μg/ml, respectively). Anhydroerythromycin A also inhibits steroid 6β-hydroxylase activity associated with the cytochrome P450 (CYP) isoform CYP3A in human liver microsomes.
|
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- HY-N2099
-
|
Autophagy
|
Neurological Disease
|
Onjisaponin B is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease .
|
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- HY-B1855
-
Epoxyheptachlor
|
Biochemical Assay Reagents
|
Others
|
(±)-cis-Heptachlor epoxides, are degradation products of heptachlor that can occur in or on soil and crops when treated with heptachlor, a pesticide. Heptachlor is readily formed upon exposure to air. Everett CJ, Thompson OM. Environmental Health Pastor. 2015;30(2):93-7.
|
-
- HY-113432S
-
|
Endogenous Metabolite
PARP
|
Metabolic Disease
|
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].
|
-
- HY-W017389S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Xanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
|
-
- HY-B0300
-
D-(-)-Penicillamine
|
Cuproptosis
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .
|
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- HY-101981S
-
5'-?Uridylic acid-15N2
|
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate-15N2 is the 15N labeled Uridine 5'-monophosphate[1]. Uridine 5'-monophosphate (5'- Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[2].
|
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- HY-101981S4
-
5'-Uridylic acid-13C9 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 13C9 (5'-?Uridylic acid- 13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-101981S5
-
5'-Uridylic acid-15N2 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 15N2 (5'-?Uridylic acid- 15N2) dilithium is 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-101981S2
-
5'-Uridylic acid-d11 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate-d11 (5'-?Uridylic acid-d11) dilithium is deuterium labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-W105318
-
PBP
|
TGF-beta/Smad
Apoptosis
|
Cancer
|
Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs) .
|
-
- HY-129611
-
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
Bromelain is an anti-inflammatory agent derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway . Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death .
|
-
- HY-W007376
-
3-Formylindole
|
Endogenous Metabolite
|
Others
|
Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .
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-
- HY-W093282
-
Soybean oil epoxide
|
Biochemical Assay Reagents
|
Others
|
Epoxidized soya bean oil (ESBO) is a vegetable oil-derived organic compound used as a plasticizer and stabilizer in various applications. It is produced by epoxidation of soybean oil, which introduces epoxy groups into the fatty acid chains of the oil. ESBO is a viscous, pale yellow liquid that is soluble in many organic solvents, such as chloroform and ethanol, but insoluble in water. It is commonly used as a plasticizer in polyvinyl chloride (PVC) products, including toys, food packaging materials and medical devices. In addition to its plasticizing properties, ESBO acts as an antioxidant and UV stabilizer, helping to prevent degradation and discoloration of PVC products over time. ESBOs have been investigated for their potential use in biodegradable plastics and as bio-based alternatives to traditional petroleum-derived plasticizers.
|
-
- HY-P4846
-
|
CXCR
|
Inflammation/Immunology
|
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
|
-
- HY-101981S3
-
5'-Uridylic acid-13C9,15N2 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 13C9, 15N2 (5'-?Uridylic acid- 13C9, 15N2) dilithium is 13C and 15N-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-W007376S
-
3-Formylindole-13C3
|
Isotope-Labeled Compounds
|
Others
|
Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
|
-
- HY-101981S1
-
5'-Uridylic acid-15N2,d11 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 15N2,d11 (5'-?Uridylic acid- 15N2,d11) dilithium is deuterium and 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-W093282
-
Soybean oil epoxide
|
Biochemical Assay Reagents
|
Epoxidized soya bean oil (ESBO) is a vegetable oil-derived organic compound used as a plasticizer and stabilizer in various applications. It is produced by epoxidation of soybean oil, which introduces epoxy groups into the fatty acid chains of the oil. ESBO is a viscous, pale yellow liquid that is soluble in many organic solvents, such as chloroform and ethanol, but insoluble in water. It is commonly used as a plasticizer in polyvinyl chloride (PVC) products, including toys, food packaging materials and medical devices. In addition to its plasticizing properties, ESBO acts as an antioxidant and UV stabilizer, helping to prevent degradation and discoloration of PVC products over time. ESBOs have been investigated for their potential use in biodegradable plastics and as bio-based alternatives to traditional petroleum-derived plasticizers.
|
-
- HY-B1855
-
Epoxyheptachlor
|
Biochemical Assay Reagents
|
(±)-cis-Heptachlor epoxides, are degradation products of heptachlor that can occur in or on soil and crops when treated with heptachlor, a pesticide. Heptachlor is readily formed upon exposure to air. Everett CJ, Thompson OM. Environmental Health Pastor. 2015;30(2):93-7.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-106263B
-
|
Peptides
|
Cancer
|
Tyroserleutide hydrochloride, isolated from the degradation products of porcine spleen , is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo .
|
-
- HY-P4372
-
|
Peptides
|
Others
|
Hepcidin-22 (human) is an inactive degradation product of hepcidin-25 that is present in the urine .
|
-
- HY-P4724
-
|
Peptides
|
Metabolic Disease
|
(β-Asp28)-Exenatide is a potential degradation product of exenatide produced by the formation and cleavage of asparagine.
|
-
- HY-106263
-
|
Peptides
|
Cancer
|
Tyroserleutide (YSL), isolated from the degradation products of porcine spleen , is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo .
|
-
- HY-106263A
-
|
Peptides
|
Cancer
|
Tyroserleutide TFA, isolated from the degradation products of porcine spleen , is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo .
|
-
- HY-P4386
-
|
GLP Receptor
|
Metabolic Disease
|
(Asp28)-Exenatide is a degradation product of exenatide (HY-13443). (Asp28)-Exenatide can be used as a GLP-1R agonist .
|
-
- HY-P3675
-
|
GnRH Receptor
|
Endocrinology
|
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes .
|
-
- HY-122542
-
|
PAI-1
|
Cardiovascular Disease
|
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .
|
-
- HY-P3674
-
|
GnRH Receptor
|
Endocrinology
|
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .
|
-
- HY-P4846
-
|
CXCR
|
Inflammation/Immunology
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Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
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Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-131122S
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4-Nonylphenol-d5 is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].
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- HY-113432S
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Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].
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- HY-B0300S
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Penicillamine-d3 is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
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- HY-101417S1
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Diethyl phosphate-d10-1 is the deuterium labeled Diethyl phosphate[1]. Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.
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- HY-W010593S
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Ethylenethiourea-d4 is the deuterium labeled Ethylenethiourea[1]. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active[2][3].
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- HY-W017389S
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Xanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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- HY-101981S
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Uridine 5'-monophosphate-15N2 is the 15N labeled Uridine 5'-monophosphate[1]. Uridine 5'-monophosphate (5'- Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[2].
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- HY-101981S4
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Uridine 5'-monophosphate- 13C9 (5'-?Uridylic acid- 13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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- HY-101981S5
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Uridine 5'-monophosphate- 15N2 (5'-?Uridylic acid- 15N2) dilithium is 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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- HY-101981S2
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Uridine 5'-monophosphate-d11 (5'-?Uridylic acid-d11) dilithium is deuterium labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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- HY-101981S3
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Uridine 5'-monophosphate- 13C9, 15N2 (5'-?Uridylic acid- 13C9, 15N2) dilithium is 13C and 15N-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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- HY-W007376S
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Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
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- HY-101981S1
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Uridine 5'-monophosphate- 15N2,d11 (5'-?Uridylic acid- 15N2,d11) dilithium is deuterium and 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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